Chapter 244 Platform Test
Wang Wentao felt a little heavy. From what his grandmother described to him, Wang Wentao could basically tell that his grandmother's disease had begun to worsen.
This is a very typical spatial cognitive error.
In the later stages of Alzheimer's disease, patients will completely lose their spatial cognition abilities.
To use a less vivid metaphor, it is like floating in pitch black space, unable to distinguish up, down, left, and right.
Wang Wentao knew that his grandmother's disease was developing in this direction.
Fortunately, his grandma didn't fall anywhere this time.
After walking out of the ward, Wang Wentao looked at his mother and asked: By the way, Mom, when I went back to school, didn't I tell you to take your grandma to a neurology department and let the doctor check her out? .”
How are the doctor's examination results?
After listening to Wang Wentao's words, Wang Wentao's mother's face showed a little embarrassment: Aren't you in the hospital now? When your grandma is discharged from the hospital, I will go to the neurology department and let the doctor take a look at your grandma.
When Wang Wentao heard this, he was stunned for a moment: Mom, you haven't taken grandma for a checkup yet, have you?
Wang Wentao's mother looked a little embarrassed: We have just celebrated the New Year, so we are busy. We can't spare the time to take your grandma to the hospital.
And that neighbor really doesn't have much contact with your grandma on weekdays. Isn't it normal that your grandma doesn't remember it? It may not be as serious as you think.
Wang Wentao couldn't help but frown. He wanted to say something, but he opened his mouth and finally closed it helplessly.
Wang Wentao knew very well that in the eyes of his parents' generation, it was normal for the elderly to forget things as they got older. Wang Wentao's speculations were also groundless and not that serious.
But this is often how Alzheimer's disease begins to progress rapidly, step by step.
Wang Wentao sighed: Mom, when your grandma is discharged from the hospital, you must remember to take her for a check-up.
I know, I know, so does your child. Faced with Wang Wentao's insistence, Wang Wentao's mother could only agree.
In the next few days, Wang Wentao stayed with her in the ward. Soon, after a thorough examination, it was determined that Wang Wentao's grandma was in good health, and the doctor also gave her a discharge notice.
After dinner, Wang Wentao said: Mom, if there is nothing else, I will go back to school first. There are still things to be busy at school.
Is it so soon? I won't stay at home all night. It's not too early now. I'll have to wait until you get to school.
Upon hearing that Wang Wentao was going back to school now, Wang Wentao's mother subconsciously began to persuade her to let Wang Wentao stay for a few more days.
Wang Wentao shook his head and replied: Mom, the main reason I came back this time is to see grandma. I am relieved that grandma is fine. Moreover, I have also bought the ticket to go back to school. I still have things to do at school, so I Not much time.
After listening to Wang Wentao's words, Wang Wentao's mother hesitated for a moment, and finally sighed: Okay, be careful on the road.
I got it, Mom.
Wang Wentao waved his hand and walked out of the ward.
Early the next morning, Lu Liang opened the door of the study room and saw Wang Wentao sitting in front of the computer.
Come back so early?
Lu Liang asked curiously. He originally thought that Wang Wentao might have to wait a few days before returning.
Wang Wentao nodded: After all, the school still has things to do.
Your grandma, how is the situation? Lu Liang asked casually.
After hearing Lu Liang's question, Wang Wentao hesitated for a moment, but finally answered truthfully: Maybe it's not optimistic, other symptoms are starting to appear.
Lu Liang patted Wang Wentao on the shoulder: Don't worry, we should be able to catch up.
This sentence seemed to rekindle Wang Wentao's confidence, and he asked: Brother, how is the test going so far?
Lu Liang raised his eyebrows: Do you want to take a look? We are currently conducting behavioral experiments.
Has the data come out? Wang Wentao asked immediately.
We have some data. Lu Liang opened his computer and opened some of the behavioral experiment data sent to him by Tan Bin, a biological company.
Some of the behavioral test data that came out are related to the jumping test.
There is a 0.4 mA alternating current at the bottom of the jumping platform. If the mouse jumps off the platform, it will receive an electric shock.
Normal mice will remember this electric shock punishment and will not jump off the platform easily.
And Alzheimer's mice, after a period of time, will forget the punishment and jump off the platform.
The non-spatial memory ability of mice was judged by recording the time the mice stayed on the platform.
It can be seen from this part of the data that the number of times that the Alzheimer's disease model mice in the control group jumped off the platform during the experiment increased little by little as the days passed.
This shows that the memory of the control mice continued to decline as Alzheimer's disease progressed.
Then the mice in the test group were Alzheimer's mice treated with drugs. Compared with the control group, the number of times the mice in the test group jumped off the platform did not change much, and even a little bit in the next few days. of reduction.
This shows that the memory of the mice in the experimental group remains unchanged, Alzheimer's disease is well controlled, and there is no deterioration for the time being.
Lu Liang said: Judging from the current situation, the medicine is still effective, but it is not very obvious.
Of course, this is only part of the test data. The platform test will be recorded until the end of the experiment. The specific situation depends on all the data being released.
Wang Wentao hesitated for a moment, and then asked: Do you have the Morris water maze test data, senior brother?
The platform test can only assess the memory ability of mice, and Alzheimer's disease damages more than just memory.
Compared with the jumping platform test, the Morris water maze test is the most effective behavioral test for evaluating Alzheimer's disease. This is why Wang Wentao is so concerned about the Morris water maze test.
If the mice in the test group do not perform well in the Morris water maze, then it will be useless no matter how good the mice perform in the platform test.
In response, Lu Liang shook his head and replied: The data from the Morris water maze test will not be released until the final test is completed. It is not as fast as you think.
How long do we have to wait? Wang Wentao was obviously impatient.
Lu Liang rolled his eyes: I don't even have the patience to do a crappy test, and the platform test data has shown that everything is developing for the better, so just wait patiently.