medical simulator

It's okay to say that the things Yang Yifeng and Zhou Cheng said were found out, but it's a bit too evil to say it like this.

The rest of the graduate students and PhD students were dumbfounded, because any of what Zhou Cheng and Yang Yifeng said was probably enough to support their graduation. The level of doctoral students in the world has not yet reached such an unbelievable height. Just go down two levels and you can graduate easily.

For some looser majors, it is not difficult to graduate at a molecular level.

Zhou Cheng ignored it and continued: "We can find that TrKB is a special link and adjustment point."

"Then, we can focus on the more upstream regulatory nodes regulated by TrKB:

"Neuron surface molecules: neuron surface molecules such as Integrin, NCAM, L1, N-cadherin, etc. can regulate the expression, distribution and signal transduction of TrkB receptors.

"Signal transduction regulatory enzymes: Signal transduction regulatory enzymes such as SH2, PTP, GSK3β, etc. can regulate the activity and stability of the TrkB signaling pathway.

"Extracellular matrix components: Extracellular matrix components such as Laminin, Fibronectin, Collagen, etc. can regulate the adhesion, growth and connection of neurons.

"There are further downstream regulatory nodes:

"MEF2: MEF2 is a transcription factor involved in neuronal development and maturation that can be regulated by CREB and NF-κB signaling pathways.

"mTOR: mTOR is a cellular metabolic regulatory protein that plays an important role in neuronal growth and synaptic plasticity, and can be regulated by Akt and PI3K signaling pathways.

"MAPKAPK2: MAPKAPK2 is a cytoskeletal regulatory protein that plays an important role in neuronal morphology and connectivity and can be regulated by the ERK signaling pathway.

"Bcl-2 family: The Bcl-2 family is a group of proteins that regulate apoptosis, which plays an important role in the survival and death of neurons, and can be regulated by the Akt signaling pathway and the NF-κB signaling pathway."

At this moment, in the eyes and ears of other people, what Zhou Cheng said has become, ji li gua la, ji li gua la, just like a foreign language.

But Yang Yifeng listened very seriously.

Zhou Cheng continued: "So we can focus on more detailed areas, such as the messenger mRNA that promotes the regulation of BDNF."

"There are mainly the following—"

"BDNF mRNA: BDNF mRNA is the gene encoding the ligand BDNF of the TrkB signaling pathway, which is widely expressed in neurons and can activate the signaling pathway after binding to the TrkB receptor.

Ntrk2 mRNA: Ntrk2 mRNA is the gene encoding the TrkB receptor, which is widely expressed in neurons and can activate signaling pathways after binding to BDNF.

RasGRP1 mRNA: RasGRP1 mRNA encodes Ras guanyl releasing protein 1, which is a protein involved in signal transduction and plays an important role in the TrkB signaling pathway.

Pten mRNA: Pten mRNA encodes protein tyrosine phosphatase, which can regulate the activity of PI3K/Akt signaling pathway, thereby affecting the growth and survival of neurons.

Gab1 mRNA: Gab1 mRNA encodes cytokine receptor tyrosine kinase binding protein 1, which regulates the activity of the TrkB signaling pathway.

Shc mRNA: Shc mRNA encodes the SHC transcription factor, which plays an important role in the TrkB signaling pathway. "

When he got here, Zhou Cheng paused for a while, and after Yang Yifeng calmed down for about a minute or two, he also saw that everyone put down their pens.

But only Zhou Cheng and Yang Yifeng knew that the depth of the current discussion was still not enough to support Yang Yifeng to solve the current problem.It's not yet time to wake up Yang Yifeng.

"The main factors affecting the mRNA level of transcription of BDNF, and there are some 6"

"Nerve growth factor (NGF): NGF can activate PI3K/Akt and MAPK/ERK signaling pathways through TrkA receptors, thereby affecting the activity of TrkB signaling pathways and the expression levels of related mRNAs.

"Inflammatory factors: Inflammatory factors such as IL-6 and TNF-α can affect the activity of TrkB signaling pathway and the expression level of related mRNA by activating JAK-STAT, NF-κB and other signaling pathways.

"Neuron activity: Neuron activity can affect the activity of TrkB signaling pathway and the expression level of related mRNA through Ca2+, CREB and other signaling pathways.

"miRNA: miRNA is a type of non-coding RNA that can affect its translation and degradation by binding to mRNA targets, thereby affecting the expression level of TrkB signaling pathway-related mRNA.

"Transcription factors: Transcription factors such as CREB, NFKB, STAT3, etc. can regulate the expression level of mRNA related to TrkB signaling pathway."

"Yi Feng, have you found out? The three layers are actually a spherical body, and the one in the center is not these popular targets, but BDNF, a less popular target. I think You can work harder on this..."

"Maybe it can provide you with some ideas to solve the current problem."

After Zhou Cheng finished speaking, Yang Yifeng nodded and closed his eyes again, not knowing what he was thinking about.

And just after Zhou Cheng babbled for a while, Jiang Hong slammed the table: "Professor Ding, who was it that rumored that our doctor Zhou Cheng was just a scalpel doctor?"

"If I find out about this again, I will tear his mouth apart."

"Whether it is a thesis doctor or a scalpel doctor, it is not enough to describe our Dr. Zhou. Even if it is placed in the field of internal medicine, Zhou Cheng said that he is the fifth, and he dares to call himself the top four. It is very difficult in China. Find it out?" Jiang Hong's words were extremely complicated.

There is admiration, unwillingness, loneliness, happiness, and an inexplicable sourness.

Why does such a talent end up in orthopedics?This is simply a genius who was born for neurosurgery, why did he go to the carpenter's department?

After Ding Changle felt the different taste in Jiang Hong's words, he immediately said: "Professor Jiang, you reminded me rightly, I think that Dr. Zhou in our department is indeed a bit inferior to him, a little overqualified the meaning of."

"But it's better to have a comprehensive resume."

"Professor Jiang, don't forget that the lancet that our Dr. Zhou holds in clinical practice is not an ordinary lancet. That's why I asked him to be in charge of the trauma center." Ding Changle said Not only explained it to Jiang Hongzai, but also explained it to Zhou Cheng.

In fact, when Zhou Cheng stepped into the field of rehabilitation and made such a big move, Ding Changle carefully considered Zhou Cheng's future development direction and the speed of his professional title promotion.

I thought to wait for a while and press it again. After all, Zhou Cheng's promotion speed was a bit too fast.

But now it seems that if you really want to make the best use of everything, you still have to promote Zhou Cheng to associate professor as soon as possible, so that he can completely let go of his hands and feet.

Zhou Cheng actually found a way to solve a topic paper published in the journal of science, a way to go one step further. This kind of ability is simply unimaginable.

Zhou Cheng just smiled and said, "Professor Ding, Professor Jiang, I just discussed this direction with Yi Feng, but I didn't come up with anything."

Zhou Cheng can point it out, but in view of the 'damage' he caused to Luo Yun before, Zhou Cheng held back a little bit this time and asked Yang Yifeng to pierce the last layer of window paper by himself. To the door of the window.

Such a sense of breakthrough and support is the real position of being both a teacher and a friend, instead of carrying Yang Yifeng and throwing Yang Yifeng into the door.

Sure enough, Yang Yifeng did not disappoint Zhou Cheng!

After Zhou Cheng finished speaking, he pursed his lips: "I probably know what to do next. Thank you Zhou Cheng, thank you master, thank you Professor Jiang, and thank you fellow brothers."

"Master, for this subject, I have to do it as soon as possible, so in the next period of time, I want to invite some brothers and sisters to cooperate with me? Do you think it is suitable?"

"During this process, I will not touch some small articles that may be produced, and I will use them for graduation." Yang Yifeng asked Ding Changle for help.

The main reason is that Yang Yifeng has graduated and is now leading students. Strictly speaking, the resources in the division should no longer be occupied, but there is no way, Yang Yifeng has too few manpower available.

Ding Changle nodded.

Jiang Hong said: "How about I send you a few people?"

After Ding Changle nodded, he quickly shook his head: "Professor Jiang, there is no need for this, we still have people in the orthopedics department for the time being. Thank you for your kindness."

At this moment, people are rejected thousands of miles away.

Jiang Hong also said: "Xiao Zhou, it is a pity that I missed the opportunity to collaborate on a project with you. I sincerely invite you to come to my laboratory and research group to name a name, and just participate in the project meeting occasionally. ,do you think it's OK?"

"If you want to give money to other things, you can do it!" Jiang Hong's eyes were sincere and his tone was serious.

Full of admiration and seriousness for academics.

Chapter 465 Parallel topics

Hearing this, Zhou Cheng closed his eyes and pondered for a while, and then declined politely: "Professor Jiang, I'm really sorry, my time is quite limited now, and I may not be able to take on such a heavy responsibility."

"If I get off the position of general inpatient, I can have more free time. I'm really sorry."

Zhou Cheng is unwilling to cooperate with other teachers, it is definitely not because of their bad attitude or impiety.

And really don't have that much time.

One has to be responsible in doing things, and one cannot treat what one says as fart, and doing everything well is the most important thing.

Promise too much, and end up with no effort at all, just sit back and enjoy the rewards. Isn’t this another kind of learning style?

It is precisely because of this that Zhou Cheng resolutely put an end to such thoughts.

Hearing this, Ding Changle explained: "Professor Jiang, it's not difficult for you to be Xiao Zhou of our department. As you know, he is now the general duty of our trauma center. In addition, he has two For a superficial topic, he is still the supervisor of the master's degree in our hospital and the head of the trauma center."

"It is necessary to build this platform. These are some objective tasks and difficulties. I really can't spare so much time."

"Otherwise, our orthopedics department also has so many experimental centers, so Xiao Zhou, who is so proficient in academics, will definitely be allowed to take up some part-time jobs, but how many nails can he drive with iron?"

"Time is limited, and it's not enough to use it by hand. Clinical practice is the main purpose, so I can't get away from it."

"And!" After Ding Changle let go of his inner worries, he began to change the topic to something more relaxed: "Professor Jiang, our Comrade Xiao Zhou is still not married, and still needs to spend a certain amount of time with his girlfriend."

"Our hospital has always attached great importance to the personal problems of young comrades, right?"

"There will definitely be opportunities in the future. It's definitely not that our comrade Xiao Zhou is unwilling, but with a responsible attitude. In the future, there will definitely be opportunities for us to join forces."

Ding Changle was speaking for the orthopedics department, so he didn't underestimate himself.

The Department of Orthopedics and Neurosurgery of the Affiliated Hospital of Shonan University are the top disciplines in the country. Although relatively speaking, the comprehensive influence of neurosurgery is higher, but that was before.

This time, with Zhou Cheng's participation, if Yang Yifeng and others make a breakthrough, the comprehensive influence of the Affiliated Hospital of Shonan University will definitely increase again.

In addition, if Zhou Cheng's two topics can be successfully broken through and become a first-class diabetic foot diagnosis and treatment center in China, it will be of great help to the improvement of the hospital's comprehensive strength and influence.

Fame is part of it. It is the real purpose of the existence of a large teaching hospital and Ding Changle's pursuit to be able to solve the problems that other general tertiary hospitals can't solve.

If Hunan Province is to become a large province of medical resources, then the affiliated hospital of Shonan University must stand up, drive the whole, become a large province of medical resources, pioneer, take a leading position in the country, and promote the entire industry, The development of corresponding specialties will benefit the majority of patients.

Ding Changle has already said so, if Jiang Hong continues to pester him, he will appear ignorant.

"Oh, what a pity. Originally, our neurosurgery department had a pretty good opportunity for development. Xiao Zhou, I really want to tie you to our department."

"In that case, Professor Ding, I will take my leave first."

"Let me give you a suggestion. You should put forward the task of the general duty earlier. A talent like Xiao Zhou, sitting in this position, is a bit overqualified, really." Jiang Hong said so and left.

Ding Changle went to see him off, leaving behind a group of orthopedics staff looking at each other.

When Ding Changle came back, everyone stared at him, wondering what Ding Changle would say.

Today's Ding Changle is the chief director of the Department of Orthopedics. If he insists on promoting Zhou Cheng, he has the right to suggest that Zhou Cheng be resigned from the position of general hospital in advance. However, if Zhou Cheng wants to go further, he will only be left The associate professor gave it to him.

An associate professor who is less than 30 years old, just thinking about it is exciting!

However, Ding Changle did not mention this matter for the time being: "Yi Feng, next, let's make overall arrangements together."

"Xiao Zhou, you can join us. Although you have a laboratory outside, you can use the experimental center I am in charge of at any time. Otherwise, it would be quite troublesome and troublesome to always go outside."

Hearing the kindness from Ding Changle, Zhou Cheng nodded and said yes, "Thank you Director Ding."

"You should change your name. These three words are a bit strange."

"Yifeng, please tell me about your general arrangement. You need to continue to study in depth, and roughly how many manpower will be needed. Let's discuss the personnel allocation and task allocation together."

"Also, you guys, especially graduate students and Ph.D. students, you should seize the opportunity. Comrade Xiao Zhou from our department is not so easy to invite."

"Now he is a member of our laboratory. If you are not active, you may be actively passed by people in other departments. You will regret it." Ding Changle said to his students again in a blink of an eye.

Zhou Cheng was stunned, and thought to himself, Professor Ding, you are the sixth child.

Since when have I been in your lab?

Before I co-authored with you, I spoke for me in order to lure me to you, right?

But face to face, Zhou Cheng really couldn't refuse and disobey Ding Changle's kindness.

Yang Yifeng didn't care about these details, and said, "Master, my student hasn't come yet. He is also a professional postgraduate student. I met him once during the re-examination."

"So, I may have to borrow three juniors to help me."

"Originally, more than five were needed, but Brother Zhou Cheng should be able to split me into two for the time being, and then my plan is..."

Yang Yifeng finished his plan when Ding Changle said: "No, Yifeng, if you want three juniors, then you should spend all your time in the lab. I had a surface project two years ago and I had to finish it soon. Now, you have to pay attention to this progress."

"Well, when the time comes, you can discuss with Tianzhu which two people will follow you."

"In addition, on Zhou Cheng's side, he also has relatively heavy tasks, and he must see the results in three years' time!"

"As a result, our laboratory is really not enough manpower. In recent years, the laboratory has recruited postdoctoral mobile stations this year, but no one has entered the station."

"I can only ask the hospital to come forward and recruit some scientific research assistants to help. Alas, there is not enough manpower, trouble!" Ding Changle was quite tired.

In terms of his team, there are more than a dozen big men, plus Yang Yifeng, Qin Tianzhu, and another doctor from this hospital, there are nearly fifteen or six people, which is not a small scale. If you add Qin Tianzhu's students, Just put together a team of 20 people.

However, in the face of complicated tasks, these manpower are still not enough. This is some of the difficulties when leading the team and leading the laboratory.

Zhou Cheng said at this moment: "Yifeng, on my side, there are actually not many people. Fang Yun must not be able to move. This is a graduate student from another hospital and cannot participate in the core project."

"There are only three people, Li Chongyue, Wang Huan, and Du Yanjun."

Yang Yifeng said with a smile: "Then Guo Lin was tricked by you too. I think Peng Lingli, who followed Master, is also closer to you. I want these two."

"Master, I plan to let..."

Yang Yifeng counted the number of people.

After counting, Ding Changle nodded in agreement, but he also confessed seriously: "Yi Feng, these are all your juniors. Although you took them away, you have to take responsibility for graduation issues and graduation thesis requirements."

"If there are no graduates by that time, then I will only trouble you?"

Masters and Ph.Ds will enter different research groups to conduct research on different topics, but the research group must ensure that there are things for them to do, and they must also publish articles. In the process of helping, they can complete their own studies.