The medical black technology system of the top student

The expression of CD8+T protein is increased.

Pin1 inhibitors inhibit tumor cell proliferation, reduce collagen deposition, inhibit CAF activation and proliferation, and increase CD8+T infiltration.

Lu Liang's eyes swept over the data.

After sending them for inspection, Manager Nie quickly completed the testing of all the samples and sent the raw data results back to Lu Liang. The speed surprised Lu Liang.

He originally thought that this batch of data would have to wait for a few more days before the final data results would be available.

But no matter what, this is undoubtedly a good thing for Lu Liang. The sooner the data comes out, the better.

Lu Liang conducted a correlation analysis on all the data.

Meanwhile, in other samples, overexpression of Pin1 in tumor cells was positively correlated with tumor progression, and overexpression of Pin1 in CAFs was associated with collagen deposition and poorer survival.

Lu Liang then analyzed the situation of the signal pathway.

In addition, if the signaling pathways are analyzed, the inhibition of Pin1 can inhibit a variety of tumor signaling pathways and can increase the expression of PD-L1 and ENT1 on the surface of tumor cells.

Further analysis found that Pin1 can promote the degradation of PD-L1 and ENT1 through lysosomes by acting on phosphorylated HIP1R

By destroying tumor fibrosis, suppressing the tumor immunosuppressive microenvironment, inducing the expression of PD-L1 and ENT1, it can significantly inhibit tumors and even reach the level of tumor elimination.

Moreover, judging from the final tumor pictures of the pancreatic lesions, after using the Pin1 inhibitor, the pancreatic cancer lesions completely disappeared in 70% of the mice.

Lu Liang breathed a long sigh of relief. With this result, there should be no problems next.

Later, Lu Liang picked up his cell phone and dialed Chen Shen's number.

Zheng Wenqing arrived at the door of a ward in the inpatient department with familiarity. There was a conspicuous sign Special Ward hanging on the door of the ward.

This is the ward of Professor Wu You, chief epidemiologist at the Centers for Disease Control and Prevention.

A year ago, Professor Wu had been diagnosed with pancreatic cancer.

But unfortunately, because of the busy work at that time, after a simple operation, I didn't have time to wait for my body to recover, so I hurriedly threw myself into heavy work.

Under these heavy workloads, Professor Wu's body was also overwhelmed. During an examination this year, he discovered that pancreatic cancer had begun to recur again.

Zheng Wen knocked on the door, and a voice came from the room: Please come in.

Pushing the door open and walking in, Zheng Wen glanced around the room. The ward was clean and tidy, with a bed in the center of the room and several medical instruments next to it.

In addition, there are several chairs placed in the ward. Compared with other wards, this ward is slightly spacious.

There is a middle-aged man lying on the hospital bed. However, what is somewhat inconsistent with the identity of the middle-aged man is that the man's pale hair and thin face are what an elderly person should have.

At this moment, the man was sleeping soundly.

Next to the hospital bed sat a mother and daughter. They were family members who had come to take care of her. At this moment, the mother and daughter were full of sorrow.

After seeing Zheng Wen, Mrs. Wu had no choice but to put on a forced smile on her face: Director Zheng, you are here.

Zheng Wen also nodded towards the mother and daughter. Then he looked at the middle-aged man on the hospital bed and said, Professor Wu, are you feeling okay today?

After listening to Zheng Wen's question, Mrs. Wu suddenly frowned and looked sad.

After a moment, she sighed and said: He complained of back pain last night. The pain was unbearable and he couldn't sleep until he tossed and turned. It was not until this morning that he felt a lot of relief.

Director Zheng, we are taking the medicine you prescribed on time, but we don't see much effect. How is my husband doing now, Director Zheng?

Hearing Mrs. Wu's words, Zheng Wen was silent for a moment, and then replied: That's right, we examined Professor Wu, and through the CT scan we found that the tumor has expanded.

Then what are you waiting for? Just like last time, hurry up and do the surgery, Director Zheng! Upon hearing this, Mrs. Wu suddenly became anxious.

However, Zheng Wen shook his head: The last time I used surgery, it was because it was discovered in time and the tumor lesions on the pancreas could be solved through surgery.

But after this recurrence, the situation is completely different from last time. This cannot be solved by surgery.

Having said this, Zheng Wen paused, and then continued: And considering Professor Wu's age and the possibility of poor prognosis after surgery,

We have been using paclitaxel + gemcitabine drug chemotherapy for conservative treatment.

But now it seems that chemotherapy is not very effective.

Mrs. Wu frowned: Is there no other way?

Zheng Wen hesitated for a moment: Yes, there is. However, as Professor Wu, this method may be inappropriate, so I came here today to ask for your opinions.

What can I do? Mrs. Wu asked anxiously.

This is the situation now, and Mrs. Wu doesn't care about anything else. It's better to have a solution than just staring here.

Zheng Wen said: That's right, a targeted drug for the treatment of pancreatic cancer has recently been developed, I think.

Mrs. Wu said directly without thinking: Then what are you waiting for? Director Zheng, hurry up and prescribe medicine for my husband.

Mrs. Wu, please listen to what I have to say first.

Zheng Wen comforted Mrs. Wu, and then continued: It's just that this targeted drug is still in clinical trials. If you want to use this drug, you need to agree to sign.

When she heard this, Mrs. Wu was stunned for a moment. Even though she didn't understand these things, she still understood the meaning of this sentence.

Medicine is not guaranteed.

no.

The person who spoke was not Mrs. Wu, but Professor Wu's daughter, a young girl in her twenties. She immediately rejected Zheng Wen's proposal.

Zheng Wen could only explain: “Actually, the development of this pancreatic cancer targeted drug was led by researcher Lu from the Institute of Drug Research.

He has also developed drugs for lung cancer and liver cancer before. I think there is still a lot of opportunity for targeted drugs for pancreatic cancer this time.

Professor Wu's daughter shook her head and said: Director Zheng, I know that person, and I also know that he is very powerful, but this is always a clinical drug.

No matter how high the chance of being effective is, no one can guarantee whether there will be other risks.

But my father's disease cannot tolerate any mistakes, so I don't agree to use this drug.

Zheng Wen didn't say anything because the decision-making power in this matter lies with the patient's family and he has no right to make any decision.